1.Yes, it working with S1. Plug either port into USB2 or 3, and the other port plug into power supply.
2.No, you can't. If you do so, some game will change input device between M&K and controller frequently and the other game will only detect one device. Maybe that will cause unpredictable problem.
3.No, it doesn't.
4.In some ways, that is right. You need to use GHUB to set the mouse, and save settings into on-board memory. We recommend 5000dpi and 500 polling rate.