you may try the following steps:
1. right click "Cross Hair Manager"
2. and then choose "run as administrator"
btw, can you map mouse buttons?
if you can't fix it, please provide some more details of your computer and OS.
PS1:
you can also do the mappings in config mode,
as showed in this video:
ReaSnow Cross Hair Mapping buttons in game
http://youtu.be/aP_9wE4EWBgPS2:
there is another way to do the mapping,
as showed in page 12(the second one) in "CrossHair-UserManual-V5.1.pdf",
which can be found here:
http://www.reasnow.com/forum/index.php?topic=28.0